Vaccines on Trial

Investigating the research on vaccines, one study at a time.

Saturday, February 6, 2016

O1010 - Active Immunization Against Tetanus

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This study looked at antibody levels in subjects immunized with various kinds of tetanus vaccine. So nothing that new. But the discussion w...
Saturday, January 16, 2016

101 - Prophylaxis and treatment of whooping cough with a pertussis antigen

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This was an unusual study on a vaccine-like method of protecting children from whooping cough. Instead of using whole killed bacterial cell...
Saturday, December 12, 2015

100 - A Comprehensive Study of Influenza in a Rural Community

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Ok, here's another study that doesn't look at vaccines specifically, but rather the background of the disease they prevent, and how...
Saturday, October 24, 2015

099 - Secondary Familial Attack Rates from Pertussis in Vaccinated and Unvaccinated Children

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This study is a follow-up analysis of previous results by Kendrick and Eldering of a clinical trial in Grand Rapids, Michigan, of a whole-c...
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Saturday, October 10, 2015

O984 - Tetanus Immunization

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The author of this study (Philip B. Cowles) seemed skeptical of some claims made about the tetanus toxoid vaccine, so set out to test them....
Saturday, September 19, 2015

O983 - Active Immunization Against Tetanus Infection with Refined Tetanus Toxoid

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This study compared unrefined tetanus toxoid and also a refined version, precipitated with alum (aluminum potassium sulfate) in guinea pigs...
Saturday, September 12, 2015

098 - Anaphylaxis after Injection of Tetanus Toxoid

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I once read an article questioning the safety and usefulness of the tetanus vaccine. This vaccine is made of the tetanus toxin itself, dena...
Saturday, August 1, 2015

097 - An Experiment in Immunization Against Influenza with a Formaldehyde-Inactivated Virus

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There had been some good results in animals with vaccines against influenza, and possibly some good trials in humans too, though not in oth...
Sunday, July 26, 2015

O953 - Prophylactic immunization against measles, scarlet fever, diphtheria, whooping cough, and influenza

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This paper was a speech given by Sir Ledingham, director of the Lister Institute in London. He says some interesting things. Speaking on th...
Sunday, July 12, 2015

096 - Active immunization against pertussis: Final report on the cleveland immunizations of 1934-1935

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This is a follow-up to an interim report on a big trial of whooping cough vaccine ( 065 ). That report didn't show much difference betw...
Saturday, June 27, 2015

095 - The Agglutinative Reaction in Relation to Pertussis and to Prophylactic Vaccination against Pertussis with Description of a New Technic

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One big question is whether you can tell if someone is immune to a disease (with methods other than exposing them and seeing if they get si...
Saturday, June 20, 2015

094 - Active Immunization Against Whooping-Cough

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This study has two parts, both relating to whooping cough vaccination. The first seems like a brief summary of a clinical trial, and the se...
Saturday, June 13, 2015

093 - H. pertussis Vaccines: The Effect of Washing and the Use of Mouse Protection Tests

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In previous studies of whooping cough vaccines, most showed protection but a few did not, and it wasn't really clear why these studies ...
Sunday, May 24, 2015

092 - Immunization against pertussis

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This is another trial of a pertussis vaccine, similar to the others. The justification was that whooping cough is contagious before it is e...
Saturday, May 16, 2015

091 - Active immunization against whooping cough with various specific vaccines

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Since various different trials of whooping cough vaccines had given confusing positive and negative results, Morris Siegel wanted to settle...
Saturday, May 9, 2015

O850 - Tetanus Bacillus Recovered from Scar Ten Years after Attack

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When active, the bacteria that cause tetanus can only survive in conditions completely lacking in oxygen, but they can form very tough spor...
Saturday, May 2, 2015

090 - Serologic Studies in Epidemic Influenza: With Particular Reference to the Persistence of Antibodies After Infection

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Many virus infections seem to lead to long-term immunity, so you get it only once; at least, that's how it seemed. But one obvious exce...
Saturday, April 25, 2015

O951 - Does an attack of acute anterior poliomyelitis confer adequate immunity? Report of four second attacks in New York City in 1935

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There've been other reports of reinfection with polio after an initial infection ( 077 ), so it seems immunity is not always lifelong o...
Friday, April 24, 2015

O860 - Investigation on Volunteers Infected with the Influenza Virus

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Apparently back in the 30s, the Soviet Union was doing research on influenza, some of which used human volunteers. 1 Well, better flu rese...
Saturday, April 11, 2015

089 - Treatment of pertussis with the New York State pertussis vaccine

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Some investigators in 1936 questioned the effectiveness of any whooping cough vaccine developed thus far, though most thought they were help...
Saturday, April 4, 2015

088 - Studies in whooping cough: Diagnosis and immunization

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First, the scary numbers: in 1936, there were more than 300,000 cases of whooping cough in the US, and 15% of infected infants died from it...
Saturday, March 21, 2015

O936 - Complications and Sequelæ of Measles

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In 1904, smallpox and diphtheria were fairly under control, so fever-causing diseases and malnutrition were the most important destroyers o...
Saturday, March 14, 2015

087 - Schick Immunity and Diphtheria Infection

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Diphtheria is a bacterial infection that can be pretty serious and deadly, especially in children. Fortunately we can form very good immuni...
Saturday, January 24, 2015

Measles and Disneyland: Just the Facts

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This is a bit different from my usual style, but a friend of mine on Facebook posted a link to a blog called "Measles Shmeasles Goes t...
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